3-[4-(3-Bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester → 3-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid

HRID 1822268Notes

Reaction equation

HRID 1822268 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:21].[CH2:23]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:26]=1)[CH3:24]>>[CH2:23]([C:25]1[CH:30]=[CH:29][C:28]([O:31][C:15]2[CH:14]=[C:13]([CH:18]=[C:17]([F:19])[CH:16]=2)[O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:22])=[C:7]([CH3:21])[CH:8]=2)=[C:27]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:26]=1)[CH3:24]

Participants

3

Reactant 2

HCID 578942333-[4-(3-Bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl esterHCID 587537954-Ethyl-2-phenoxy-phenol

Product 1

HCID 112602843-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid

Procedure

The title compound is prepared by reacting the compound of 3-[4-(3-bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 4-ethyl-2-phenoxy-phenol as in Example 18 to afford 0.139 g (52%). 1H NMR (400 MHz, CDCl3); MS (ES−) m/z mass calculated for C30H27O5F 486, found 485 (M−1).

Workup

  1. customto afford 0.139 g (52%)

Sources & evidence

ORD record
ord-83a8955a655e4cb18081da249ee66225
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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