HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(3-Bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester → 3-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(3-Bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester | HCID 57894233 | — |
| Reactant | 4-Ethyl-2-phenoxy-phenol | HCID 58753795 | — |
| Product | 3-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid | HCID 11260284 | — |
Reaction Steps
The title compound is prepared by reacting the compound of 3-[4-(3-bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 4-ethyl-2-phenoxy-phenol as in Example 18 to afford 0.139 g (52%). 1H NMR (400 MHz, CDCl3); MS (ES−) m/z mass calculated for C30H27O5F 486, found 485 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608639B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-83a8955a655e4cb18081da249ee66225 |
| Source note | uspto-grants-2009_10 |