反应详情

A mixture of 3-[4-(3-benzyloxy-5-methyl-phenoxy)-2-methyl-phenyl]-acrylic acid ethyl ester (3.56 g, 88.5 mmol) and 10% Pd/C (1.75 g) in ethyl acetate (90 mL) is purged with N2, then purged with H2 and stirred under a hydrogen balloon. Upon completion, the mixture is filtered through hyflo, and the solvent is removed in vacuo to afford 2.83 g (100%) the title compound. Rf=0.35 (2/1 hexanes/EtOAc). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C19H22O4 314, found 315 (M+1, 100%).

1. customis purged with N2
2. custompurged with H2
3. filtrationUpon completion, the mixture is filtered through hyflo
4. customthe solvent is removed in vacuo