HRID1822291

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734309

2-Acetylphenylboronic acid

C8H9BO3

结构：CCOC(=O)CCc1ccc(Oc2cc(C)cc(Oc3ccc(C(F)(F)F)cc3Br)c2)cc1C

HCID57894173

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1ccccc1-c1cc(C(F)(F)F)ccc1Oc1cc(C)cc(Oc2ccc(CCC(=O)O)c(C)c2)c1

HCID11330263

未命名化合物

PROCEDURE

实验过程

The title compound is prepared by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 2-acetyl phenyl boronic acid as in Example 38 to afford 0.032 g (28%).

WORKUP

后处理

customto afford 0.032 g (28%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d52afd48acd34d2a92536e9754dea021
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07608639B2
来源说明: uspto-grants-2009_10

反应 SMILES

C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[C:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1B(O)O)(=[O:37])[CH3:36]>>[C:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[C:27]1[CH:26]=[C:25]([C:28]([F:30])([F:31])[F:29])[CH:24]=[CH:23][C:22]=1[O:21][C:16]1[CH:15]=[C:14]([CH:19]=[C:18]([CH3:20])[CH:17]=1)[O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:34])=[O:3])=[C:8]([CH3:33])[CH:9]=1)(=[O:37])[CH3:36]