2-Acetylphenylboronic acid → 3-{4-[3-(2'-Acetyl-5-trifluoromethyl-biphenyl-2-yloxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid

HRID 1822291Notes

Reaction equation

HRID 1822291 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[C:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1B(O)O)(=[O:37])[CH3:36]>>[C:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[C:27]1[CH:26]=[C:25]([C:28]([F:30])([F:31])[F:29])[CH:24]=[CH:23][C:22]=1[O:21][C:16]1[CH:15]=[C:14]([CH:19]=[C:18]([CH3:20])[CH:17]=1)[O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:34])=[O:3])=[C:8]([CH3:33])[CH:9]=1)(=[O:37])[CH3:36]

Participants

3

Reactant 2

HCID 27343092-Acetylphenylboronic acidHCID 57894173HCID 57894173, compound

Product 1

HCID 113302633-{4-[3-(2'-Acetyl-5-trifluoromethyl-biphenyl-2-yloxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid

Procedure

The title compound is prepared by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 2-acetyl phenyl boronic acid as in Example 38 to afford 0.032 g (28%).

Workup

  1. customto afford 0.032 g (28%)

Sources & evidence

ORD record
ord-d52afd48acd34d2a92536e9754dea021
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

Loading…