反应详情

A solution of 3-{2-methyl-4-[3-methyl-5-(2-phenoxy-4-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-propionic acid ethyl ester (0.137, 0.249 mmol) in ethanol (8 mL) is treated with 5 N NaOH (2 mL) and heated to reflux until saponification is completed. The mixture is cooled, and the solvent is removed in vacuo to afford a residue that is acidified with 1 N HCl. The mixture is diluted with water and extracted with ethyl acetate. The organic layer is dried (Na2SO4), and the solvent is removed in vacuo to afford 0.143 g (100%) of the title compound. 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C30H25O5F3 523.1732, found 523.1721.

1. temperatureheated
2. temperatureto reflux until saponification
3. temperatureThe mixture is cooled
4. customthe solvent is removed in vacuo
5. customto afford a residue that
6. extractionextracted with ethyl acetate
7. dry with materialThe organic layer is dried (Na2SO4)
8. customthe solvent is removed in vacuo