3-Hydroxypyridine → HCID 11375888, compound

HRID 1822298Notes

Reaction equation

C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[OH:35][C:36]1[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=1>>[CH3:33][C:8]1[CH:9]=[C:10]([O:13][C:14]2[CH:15]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:30])([F:29])[F:31])=[CH:24][C:23]=3[O:35][C:36]3[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=3)[CH:17]=[C:18]([CH3:20])[CH:19]=2)[CH:11]=[CH:12][C:7]=1[CH2:6][CH2:5][C:4]([OH:3])=[O:34]

Participants

Reactant 2

HCID 79713-Hydroxypyridine

HCID 57894173HCID 57894173, compound

Product 1

HCID 11375888HCID 11375888, compound

Procedure

The title compound is prepared by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 3-hydroxypyridine as in Example 45 to afford 0.044 g (31%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C29H24NO5F3 524.1685, found 524.1680.

Workup

customto afford 0.044 g (31%)

Sources & evidence

ORD record: ord-0fb8902ae3aa4b26a1baced107b80852
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07608639B2

Reaction notes

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