O-Cresol → HCID 11478190, compound

HRID 1822299Notes

Reaction equation

HRID 1822299 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[C:35]1([CH3:42])[C:40]([OH:41])=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH3:33][C:8]1[CH:9]=[C:10]([O:13][C:14]2[CH:15]=[C:16]([O:21][C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:30])([F:31])[F:29])=[CH:26][C:27]=3[O:41][C:40]3[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=3[CH3:42])[CH:17]=[C:18]([CH3:20])[CH:19]=2)[CH:11]=[CH:12][C:7]=1[CH2:6][CH2:5][C:4]([OH:34])=[O:3]

Participants

3

Reactant 2

HCID 335O-CresolHCID 57894173HCID 57894173, compound

Product 1

HCID 11478190HCID 11478190, compound

Procedure

The title compound is prepared by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with o-cresol as in Example 45 to afford 0.038 g (25%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) 71 m/Z exact mass calculated for C31H27O5F3 537.1888, found 537.1893.

Workup

  1. customto afford 0.038 g (25%)

Sources & evidence

ORD record
ord-b1c03c8c725d4c77a32ec9826a5be5a2
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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