HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)pyridine → 3-{4-[3-Fluoro-5-(2-pyridin-2-yl-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)pyridine | HCID 607784 | — |
| Reactant | HCID 57894125 | HCID 57894125 | — |
| Product | 3-{4-[3-Fluoro-5-(2-pyridin-2-yl-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid | HCID 11237570 | — |
Reaction Steps
The title compound is prepare by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 2-tributylstannyl pyridine as in Example 39 to afford 0.085 g (36%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C28H21NO4F4 512.1485, found 512.1487.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608639B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-11902441b2ef4c43933aae0da97fd1aa |
| Source note | uspto-grants-2009_10 |