4-Chloro-2-phenoxyphenol → 3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-5-ethyl-phenoxy]-2-methyl-phenyl}-propionic acid
Reaction equation
C[O:2][C:3](=[O:23])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[C:17]([CH2:19][CH3:20])[CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:22].[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:26]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][C:15]2[CH:14]=[C:13]([CH:18]=[C:17]([CH2:19][CH3:20])[CH:16]=2)[O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:23])=[C:7]([CH3:22])[CH:8]=2)=[C:27]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:26]=1Participants
3
Procedure
The compound of 3-[4-(3-bromo-5-ethyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester is reacted with 4-chloro-2-phenoxy-phenol as in Example 18 to afford 0.237 g (36%) of the title compound after saponification. 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C30H28O5Cl 503.1625, found 503.1625.
Sources & evidence
- ORD record
- ord-096e1a8f508b4890b1aa7b25eab3051b
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07608639B2
Reaction notes
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