O-Cresol → HCID 11341160, compound

HRID 1822339Notes

Reaction equation

C[O:2][C:3](=[O:32])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][C:21]=3Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:31].[C:33]1(C)[C:38]([OH:39])=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:31][C:7]1[CH:8]=[C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:28])([F:29])[F:27])=[CH:22][C:21]=3[O:39][C:38]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[CH:14]=2)[CH:10]=[CH:11][C:6]=1[CH2:5][CH2:4][C:3]([OH:2])=[O:32]

Participants

Reactant 2

HCID 335O-Cresol

HCID 57894211HCID 57894211, compound

Product 1

HCID 11341160HCID 11341160, compound

Procedure

The title compound is prepare by reacting the compound of 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester with o-cresol as in Example 45 to afford 0.229 g (21%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H25O5F3 522, found 523 (M+1, 100%).

Workup

customto afford 0.229 g (21%)

Sources & evidence

ORD record: ord-9eb2a372c89245d78be79c9252c4ea39
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07608639B2

Reaction notes

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