O-Cresol → HCID 57894126, compound

HRID 1822355Notes

Reaction equation

[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O:10][C:11](=[O:40])[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([O:27][C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:29]=3Br)[CH:22]=2)=[CH:16][C:15]=1[CH3:39]>>[CH3:39][C:15]1[CH:16]=[C:17]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([O:27][C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:36])([F:37])[F:35])=[CH:30][C:29]=3[O:7][C:6]3[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=3[CH3:8])[CH:22]=2)[CH:18]=[CH:19][C:14]=1[CH2:13][CH2:12][C:11]([OH:40])=[O:10]

Participants

Reactant 2

HCID 335O-Cresol

HCID 57894211HCID 57894211, compound

Product 1

HCID 57894126HCID 57894126, compound

Procedure

The title compound is prepared according to Example 38 by using o-cresol and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 229 mg (21%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H25O5F3 522, found 523 (M+1, 100%).

Workup

customto afford about 229 mg (21%)

Sources & evidence

ORD record: ord-2e985cd1f1e945828be795a990bfc7a7
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07608639B2

Reaction notes

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