Phenylboronic Acid → HCID 57894185, compound

HRID 1822360Notes

Reaction equation

[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O:11][C:12](=[O:41])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][C:30]=3Br)[CH:23]=2)=[CH:17][C:16]=1[CH3:40]>>[CH3:40][C:16]1[CH:17]=[C:18]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][C:30]=3[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH:23]=2)[CH:19]=[CH:20][C:15]=1[CH2:14][CH2:13][C:12]([OH:11])=[O:41]

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 57894211HCID 57894211, compound

Product 1

HCID 57894185HCID 57894185, compound

Procedure

The title compound is prepared according to Example 89 by using phenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 74 mg (49%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C29H23O4F3 492, found 493 (M+1, 100%).

Workup

customto afford about 74 mg (49%)

Sources & evidence

ORD record: ord-b29917a3b14245f69d76357b77193502
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07608639B2

Reaction notes

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