Methylamine → HCID 68489029, compound

HRID 1822437Notes

Reaction equation

HRID 1822437 reaction equation
CO[C:3](=[O:27])[CH:4]([NH:11][C:12](=[O:26])[CH:13]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:14]([CH3:17])([CH3:16])[CH3:15])[CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[CH3:28][NH2:29]>CCO.C1COCC1>[C:22]([O:21][C:19](=[O:20])[NH:18][CH:13]([C:12](=[O:26])[NH:11][CH:4]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[C:3](=[O:27])[NH:29][CH3:28])[C:14]([CH3:17])([CH3:15])[CH3:16])([CH3:24])([CH3:25])[CH3:23]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 68492663HCID 68492663, compound

Product 1

HCID 68489029HCID 68489029, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

To compound 19 in EtOH-THF 1:2 was added a large excess of methylamine (30% in water) and left at rt. for 2 weeks. The solution was concentrated to dryness and the residue subjected to a short silica gel column eluted with 2% MeOH in dichloromethane to give a pure (>95%) product M+H+384.5.

Workup

  1. waitleft at rt
  2. waitfor 2 weeks
  3. concentrationThe solution was concentrated to dryness
  4. washeluted with 2% MeOH in dichloromethane

Sources & evidence

ORD record
ord-ce228e63f8d14c5b95c1d899e3310369
Source dataset
uspto-grants-2009_10
Patent number
US07608590B2

Reaction notes

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