HCID 68489029, compound → HCID 68491417, compound

HRID 1822438Notes

Reaction equation

HRID 1822438 reaction equation
C(OC(=O)[NH:7][CH:8]([C:13](=[O:26])[NH:14][CH:15]([CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)[C:16](=[O:19])[NH:17][CH3:18])[C:9]([CH3:12])([CH3:11])[CH3:10])(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[NH2:7][CH:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:13]([NH:14][CH:15]([CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1)[C:16](=[O:19])[NH:17][CH3:18])=[O:26]

Participants

3

Reactant 1

HCID 68489029HCID 68489029, compound

Product 1

HCID 68491417HCID 68491417, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Compound 20 was kept in dichloromethane-trifluoroacetic acid 2:1 for 1 h at rt and concentrated to dryness. The residue was dried in a vacuum for 16 hrs. Reversed phase C18 HPLC showed >95% purity M+H+283.1.

Workup

  1. customfor 1 h
  2. customat rt
  3. concentrationconcentrated to dryness
  4. customThe residue was dried in a vacuum for 16 hrs

Sources & evidence

ORD record
ord-12b96bb212384a99b53aff70d0acaa1b
Source dataset
uspto-grants-2009_10
Patent number
US07608590B2

Reaction notes

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