Toluene → HCID 68493037, compound

HRID 1822461Notes

Reaction equation

HRID 1822461 reaction equation
C(OC([N:8]1[CH2:31][C@H:30]([O:32][C:33]2[C:42]3[C:37](=[CH:38][C:39]([O:43][CH3:44])=[CH:40][CH:41]=3)[N:36]=[C:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)[CH:34]=2)[CH2:29][C@H:9]1[C:10]([NH:12][C@H:13]([C:17]([NH:19][S:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)(=[O:22])=[O:21])=[O:18])[CH2:14][CH2:15][CH3:16])=[O:11])=O)(C)(C)C.C1(C)C=CC=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH3:44][O:43][C:39]1[CH:38]=[C:37]2[C:42]([C:33]([O:32][C@H:30]3[CH2:31][NH:8][C@H:9]([C:10]([NH:12][C@H:13]([C:17]([NH:19][S:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)(=[O:22])=[O:21])=[O:18])[CH2:14][CH2:15][CH3:16])=[O:11])[CH2:29]3)=[CH:34][C:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)=[N:36]2)=[CH:41][CH:40]=1

Participants

4

Reactant 2

HCID 1140TolueneHCID 68491072HCID 68491072, compound

Product 1

HCID 68493037HCID 68493037, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Compound 72 was kept in DCM-TFA 2:1 (2 mL) for 2.5 hr at RT. The solution was co-evaporated with toluene to dryness. Yield 100%. M+H 603.12

Sources & evidence

ORD record
ord-5836c00abf8048eaa0d6d195da855186
Source dataset
uspto-grants-2009_10
Patent number
US07608590B2

Reaction notes

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