反应详情

Potassium butoxide (0.5 g) was added to a THF (10 mL) solution of allyl 2-{3-(2,6-difluorophenyl)pyrazol-1-yl}acetate (0.5 g) and 5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carbonyl chloride (0.44 g) at 0° C., and stirred for 5 minutes. Water (5 ml) was added thereto, and then extracted with diluted hydrochloric acid and ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, and then concentrated, and the resulting concentrate was purified through silica gel column chromatography (chloroform) to obtain the intended product, Compound No. I-133 (0.89 g).

1. extractionextracted with diluted hydrochloric acid and ethyl acetate
2. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
3. concentrationconcentrated
4. concentrationthe resulting concentrate
5. customwas purified through silica gel column chromatography (chloroform)
6. customto obtain the intended product, Compound No