反应详情

温度

80 °C

To a stirred solution of 2-methoxybenzonitrile (2.66 g, 20 mmol) and N-methylhydroxylamine hydrochloride (3.341 g, 40 mmol) in 2:1 water/ethanol (30 mL) was added sodium carbonate (2.332 g, 22 mmol) in small portions and the resulting pink solution stirred at 80° C. for 28 h. The reaction mixture was then concentrated and the residue stirred with CH2Cl2, filtered and concentrated to give crude product as a purple solid (3.3 g), which was used in the next step without further purification.

1. concentrationThe reaction mixture was then concentrated
2. stirringthe residue stirred with CH2Cl2
3. filtrationfiltered
4. concentrationconcentrated