HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 131725722, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | (1S)-1-phenylpropan-1-amine | HCID 6993773 | — |
| Reactant | 2-Phenyl-[1,6]naphthyridine-4-carboxylic acid | HCID 10682107 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 131725722 | HCID 131725722 | — |
Reaction Steps
To a solution of 250 mg of 2-phenylpyridino[4,3-b]pyridin-4-yl carboxylic acid dissolved in 5 mL of dimethylacetamide and 200 uL of triethylamine is added 500 mg of BOP in 5 mL of dichloroethane followed by 150 mg of (S)-1-phenylpropylamine. The reaction mixture is stirred for 16 hours at room temperature. The reaction mixture is poured onto 50 mL of 1N NaOH and the product is extracted with 25 mL of ethyl acetate. After drying over magnesium sulfate the solvent is removed in vacuo to afford N—[(S)-1-phenyl-1-propyl)]-(2-phenylpyridino[4,3-b]pyridin-4-yl)carboxamide as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07037922B1 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-9f9a46d99877422791292d7e71a718a4 |
| Source note | uspto-grants-2006_05 |