反应详情

To a solution of 250 mg of 2-phenylpyridino[4,3-b]pyridin-4-yl carboxylic acid dissolved in 5 mL of dimethylacetamide and 200 uL of triethylamine is added 500 mg of BOP in 5 mL of dichloroethane followed by 150 mg of (S)-1-phenylpropylamine. The reaction mixture is stirred for 16 hours at room temperature. The reaction mixture is poured onto 50 mL of 1N NaOH and the product is extracted with 25 mL of ethyl acetate. After drying over magnesium sulfate the solvent is removed in vacuo to afford N—[(S)-1-phenyl-1-propyl)]-(2-phenylpyridino[4,3-b]pyridin-4-yl)carboxamide as a solid.

1. extractionthe product is extracted with 25 mL of ethyl acetate
2. dry with materialAfter drying over magnesium sulfate the solvent
3. customis removed in vacuo