Acetyl chloride → HCID 23568572, compound

HRID 1822771Notes

Reaction equation

HRID 1822771 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:21])[C@H:8]([CH2:17][CH:18]([CH3:20])[CH3:19])[NH:9]C(OC(C)(C)C)=O.C([Cl:25])(=O)C>CO>[ClH:25].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:21])[C@H:8]([CH2:17][CH:18]([CH3:19])[CH3:20])[NH2:9]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 16493899HCID 16493899, compound

Product 1

HCID 23568572HCID 23568572, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-Boc-L-leucine 3-methoxypropyl amide (463 mg, 1.54 mmol) was in CH3OH (10 mL) was treated with acetyl chloride (1 mL). After 45 minutes, all volatiles were removed under reduced pressure to yield L-leucine 3-methoxypropyl amide hydrochloride (310 mg, quant.) as a sticky solid.

Workup

  1. customall volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-1d9f200111214a378dce22ad4b94c051
Source dataset
uspto-grants-2006_05
Patent number
US07037916B2

Reaction notes

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