反应详情

A solution of N, N-dimethylaniline (0.31 mL) and 6-butyl-2-(3-fluoro-phenyl)-3H-pyrimidin-4-one (0.3 g) in 6 mL phosphorus oxychloride was heated in a sealed tube for 2.5 h at 125° C. The solution was allowed to cool and the phosphorous oxychloride were removed in vacuo. The remaining residue was washed four times with diethyl ether and the combined ether portions were washed with 0.5 M hydrochloric acid, dried over magnesium sulfate, and concentrated in vacuo to yield 4-butyl-6-chloro-2-(3-fluoro-phenyl)-pyrimidine (0.20 g).

1. temperatureto cool
2. customthe phosphorous oxychloride were removed in vacuo
3. washThe remaining residue was washed four times with diethyl ether
4. washthe combined ether portions were washed with 0.5 M hydrochloric acid
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in vacuo