反应详情

Quinoline-3-nitrile (1.0 g) was dissolved in diethyl ether (30 mL) and treated with lithium bis(trimethylsilyl)amide (1.0 M in THF, 13 mL). The reaction was stirred for 3 hours, then washed 3 times with 1 N HCl (50 mL). The combined aqueous washes were neutralized with 6 N NaOH and extracted 6 times with ethyl acetate (50 mL). The ethyl acetate extractions were dried over sodium sulfate and the solvent was evaporated to provide 0.63 g of quinoline-3-carboxamidine.

1. washwashed 3 times with 1 N HCl (50 mL)
2. extractionextracted 6 times with ethyl acetate (50 mL)
3. extractionThe ethyl acetate extractions
4. dry with materialwere dried over sodium sulfate
5. customthe solvent was evaporated