Diethyl Ether → HCID 54515481, compound

Temperature

0 °C

A freshly prepared solution of sodium methoxide (prepared by dissolving sodium (0.46 g, 20 mmol) in MeOH (5 mL)) was added very slowly via a double ended needle to a solution of 3-furaldehyde (1.73 mL, 20 mM) and nitromethane (1.08 mL, 20 mmol) in MeOH (4 mL) cooled to 0° C. The mixture was stirred at 0° C. an addition 5 min, then Et2O (10 mL) was added. The resultant salt was collected via filtration, thoroughly washed with Et2O, taken up in a minimum amount of water then the solution was added to an ice cold solution of 25% HCl (80 mL). The solid that formed was collected by filtration and washed with water, then the moist product was taken up in CHCl3/MeOH and solvents removed to give 3-(2-nitrovinyl) furan (69%) as a pale yellow solid.

1. additionan addition 5 min
2. filtrationThe resultant salt was collected via filtration
3. washthoroughly washed with Et2O
4. additionthe solution was added to an ice cold solution of 25% HCl (80 mL)
5. customThe solid that formed
6. filtrationwas collected by filtration
7. washwashed with water
8. customsolvents removed

ORD record

ord-c5aa1c8f67fa4aba9972532c3f5d28ce

Source dataset

uspto-grants-2006_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07037916B2