反应详情

A suspension of 2-bromo-6-benzoylthioureidopyridine (4.99 g, 14.84 mmol) in 10% aqueous sodium hydroxide solution (10.4 mL, 26 mmol) was stirred at rt. for 10 min and then under reflux for an additional 10 min. The mixture was cooled to 0° C. and acidified with 1 N aqueous HCl solution to pH 4.0 and then adjusted to pH 8.5 with satd. aqueous potassium bicarbonate solution. The mixture was stirred at 0° C. for several min and the precipitate was filtered, washed several times with water and dried in vacuo over P2O5 to obtain the titled compound (3.23 g, 94%) as a white solid.

1. temperatureunder reflux for an additional 10 min
2. temperatureThe mixture was cooled to 0° C.
3. stirringThe mixture was stirred at 0° C. for several min
4. filtrationthe precipitate was filtered
5. washwashed several times with water
6. dry with materialdried in vacuo over P2O5