Thionyl Chloride → 1-(3-chloropropyl)-1H-1,2,4-triazole

HRID 1822836Notes

Reaction equation

[N:1]1([CH2:6][CH2:7][CH2:8]O)[CH:5]=[N:4][CH:3]=[N:2]1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][CH2:7][CH2:6][N:1]1[CH:5]=[N:4][CH:3]=[N:2]1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 47118023-(1H-1,2,4-triazol-1-yl)propan-1-ol

Product 1

HCID 167906881-(3-chloropropyl)-1H-1,2,4-triazole

Procedure

3-(1H-1,2,4-triazol-1-yl)-1-propanol (0.160 g, 1.3 mmol) was refluxed in thionylchloride (3 ml) for 2 h. The recation mixture was evaporated yielding the title product.

Workup

customThe recation mixture was evaporated

Sources & evidence

ORD record: ord-b173af9441ee4641b250be0b825fc624
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07037925B2

Reaction notes

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