反应详情

4-Nitro-1-indanone (0.84 g, 4.75 mmol) was suspended in aqueous hydrochloric acid (9 M, 40 ml) and stannous chloride (3 g, 15.8 mmol) was added. The mixture was stirred at ambient temperature. After 2 h a clear solution was obtained. The stirring was continued for 23 h after which time a yellow precipitate had formed. The reaction mixture was diluted with water and washed trice with methylene chloride. The aqueous phase was made alkaline with 2 M aqueous NaOH and extracted four times with methylene chloride. The combined organic phases was washed with water, dried (Na2SO4), filtered, evaporated and finally dried to give the title compound (630 mg, 90%).

1. customAfter 2 h a clear solution was obtained
2. customafter which time a yellow precipitate had formed
3. washwashed trice with methylene chloride
4. extractionextracted four times with methylene chloride
5. washThe combined organic phases was washed with water
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. customevaporated
9. customfinally dried