反应详情

温度

-5 °C

Triethylamine (0.97 ml; 6.34 mmol) and butanoyl chloride (0.52 ml; 5.07 mmol) were added in this order to a solution of 2-amino-5-isopropyl-1,3-thiazole (0.6 g; 4.23 mmol) in dichloromethane (8 ml), cooled to −5° C. The reaction mixture was stirred at −5° C. for 2 hours and then warmed to room temperature. After additional 4 hours, the organic layer was washed with water, saturated sodium bicarbonate, 1N hydrochloric acid, brine, dried over sodium sulfate and evaporated. The residue was recrystallized from cyclohexane to yield 0.45 g (50%) of the title compound as a colourless solid (m.p. 95–97° C.)

1. temperaturewarmed to room temperature
2. waitAfter additional 4 hours
3. washthe organic layer was washed with water, saturated sodium bicarbonate, 1N hydrochloric acid, brine
4. dry with materialdried over sodium sulfate
5. customevaporated
6. customThe residue was recrystallized from cyclohexane