Water → HCID 22170732, compound

HRID 1822882Notes

Reaction equation

HRID 1822882 reaction equation
[OH2:1].CN(N=[C:6]([CH3:20])[CH2:7][CH2:8][C:9]1[S:13][C:12]([NH:14][C:15](=[O:19])[CH2:16][CH2:17][CH3:18])=[N:11][CH:10]=1)C>O1CCCC1>[O:1]=[C:6]([CH3:20])[CH2:7][CH2:8][C:9]1[S:13][C:12]([NH:14][C:15](=[O:19])[CH2:16][CH2:17][CH3:18])=[N:11][CH:10]=1

Participants

4

Reactant 2

HCID 962WaterHCID 54222564HCID 54222564, compound

Product 1

HCID 22170732HCID 22170732, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 200 mg (1 mmol) of cupric acetate in 10 ml of water 141 mg (0.5 mmol) of N-[5-(3-dimethylaminoimino-butyl)-1,3-thiazol-2-yl]-butanamide in 10 ml of tetrahydrofuran were added. After 2 hours the solvent was removed under reduced pressure, a mixture of aqueous ammonium chloride and ammonium hydroxide was added and the product extracted with methylene chloride to give after drying and concentration 114 mg (95% yield) of the title compound.

Workup

  1. customAfter 2 hours the solvent was removed under reduced pressure
  2. additiona mixture of aqueous ammonium chloride and ammonium hydroxide
  3. additionwas added
  4. extractionthe product extracted with methylene chloride
  5. customto give
  6. customafter drying

Sources & evidence

ORD record
ord-31ebdba29ec24649a8affe0cb4284834
Source dataset
uspto-grants-2006_05
Patent number
US07037929B1

Reaction notes

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