反应详情

温度

125 °C

In a pressure tube, 0.60 mmol of 4,7-dichloro-1H-indole-2,3-dione (130 mg) and 0.65 mmol of 4-(4,5-diamino-4H-[1,2,4]triazol-3-ylmethyl)-phenol (133.5 mg) in a mixture of trifluoroethanol (8 mL) and water (4 mL) was stirred at 125° C. overnight (16 hr). The mixture was cooled to room temperature, allowed to crystallize for 2 hours. The precipitated product was collected by filtration, washed with MeOH+water 1:1, then with chilled MeOH. Dried on high vacuum.

1. temperatureThe mixture was cooled to room temperature
2. customto crystallize for 2 hours
3. filtrationThe precipitated product was collected by filtration
4. washwashed with MeOH+water 1:1
5. customDried on high vacuum