Piperidine → 1-(2-Fluoro-4-nitrophenyl)piperidine

HRID 1822920Notes

Reaction equation

HRID 1822920 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 1230531,2-Difluoro-4-nitrobenzene

Product 1

HCID 107043451-(2-Fluoro-4-nitrophenyl)piperidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3,4-Difluoronitrobenzene (1.4 mL, 2.01 g, 12.7 mmol) in piperidine (4 mL, 40.4 mmol) was heated in a sealed tube at 130° C. for 2 hours. The mixture was allowed to cool to room temperature and poured into H2O (150 mL). The title compound was separated by pipette. 1H NMR (300 MHz, DMSO-d6) δ 7.95–8.01 (m, 2H), 7.11–7.18 (m, 1H), 3.26–3.29 (m, 4H), 1.62–1.68 (m, 6H); MS (ESI+) m/z 225 (M+H)+.

Workup

  1. customThe title compound was separated by pipette

Sources & evidence

ORD record
ord-8e56e077ea6a43539c8c882afa47c21d
Source dataset
uspto-grants-2006_05
Patent number
US07037927B2

Reaction notes

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