反应详情

The product from Example 10A (12.7 mmol) was hydrogenated (balloon) as a solution in ethyl acetate over 5% Pd/C overnight at room temperature. The mixture was filtered through Celite and the filtrate was concentrated under reduced pressure to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 6.72–6.78 (m, 1H), 6.26–6.34 (m, 2H), 4.92 (br s, 2H), 2.76 (m, 4H), 1.56–1.63 (m, 4H), 1.42–1.49 (m, 2H); MS (APCI+) m/z 195.

1. customat room temperature
2. filtrationThe mixture was filtered through Celite
3. concentrationthe filtrate was concentrated under reduced pressure