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HRID1822993

反应详情

EQUATION

反应方程式

HRID 1822993 的结构方程式

REACTANTS

反应物

3
结构：Fc1cc(F)c(CBr)c(F)c1
HCID2777059

2,4,6-Trifluorobenzyl bromide

C7H4BrF3

结构：COC(=O)C1CC(=O)N(c2ccc(O)cc2)C1
HCID2883518

methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate

C12H13NO4

结构：COC(=O)C1CC(=O)N(c2ccc(OCc3c(F)cc(F)cc3F)cc2)C1
HCID68614540

未命名化合物

PRODUCTS

生成物

2
结构：CN
HCID6329

Methylamine

CH5N

结构：CNC(=O)C1CC(=O)N(c2ccc(OCc3c(F)cc(F)cc3F)cc2)C1
HCID10362262

未命名化合物

PROCEDURE

实验过程

The title compound is prepared by alkylation of the (RS)-1-(4-hydroxyphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester with 2,4,6-trifluorobenzyl bromide giving the (RS)-5-oxo-1-[4-(2,4,6-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methyl ester which, thereupon, by treatment with methylamine yields the (RS)-5-oxo-1-[4-(2,4,6-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methylamide. Yield: 97% of theory as a white solid. MS: m/e=379 (M+H)+.