Methylamine → HCID 10473446, compound

HRID 1823005Notes

Reaction equation

HRID 1823005 reaction equation
C[O:2][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=3)=[C:13]([CH3:26])[CH:12]=2)[CH2:6]1)=O.[CH3:27][NH2:28]>C(O)C>[CH3:27][NH:28][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=3)=[C:13]([CH3:26])[CH:12]=2)[CH2:6]1)=[O:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 69781444HCID 69781444, compound

Product 1

HCID 10473446HCID 10473446, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In analogy to the aminolysis described in Example 1e), the (RS)-1-[(4-(3-fluoro-benzyloxy)-3-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester is treated in a sealed tube with methylamine in ethanol at 60° C. for 18 h to yield the

Workup

  1. customto yield the

Sources & evidence

ORD record
ord-57d4f3392e9a42209bbb61ae623b4e9f
Source dataset
uspto-grants-2006_05
Patent number
US07037935B2

Reaction notes

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