Itaconic acid → HCID 21920016, compound

HRID 1823010Notes

Reaction equation

HRID 1823010 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)[CH:5]=[CH:4][C:3]=1[NH2:17].[C:18]([OH:26])(=[O:25])[C:19]([CH2:21][C:22](O)=[O:23])=[CH2:20]>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)[CH:5]=[CH:4][C:3]=1[N:17]1[C:22](=[O:23])[CH2:21][CH:19]([C:18]([OH:26])=[O:25])[CH2:20]1

Participants

3

Reactant 2

HCID 811Itaconic acidHCID 21920051HCID 21920051, compound

Product 1

HCID 21920016HCID 21920016, compound

Procedure

The title compound is prepared in analogy to Example 20c) from 2-fluoro-4-(3-fluoro-benzyloxy)-phenylamine and itaconic acid. Yield: 67% of a purple solid. MS: m/e=346.1 (M+H)+.

Sources & evidence

ORD record
ord-d924f3de54f44b159b1b08b734159f70
Source dataset
uspto-grants-2006_05
Patent number
US07037935B2

Reaction notes

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