Methylamine → HCID 10316454, compound

HRID 1823011Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)[CH:5]=[CH:4][C:3]=1[N:17]1[C:21](=[O:22])[CH2:20][CH:19]([C:23]([OH:25])=O)[CH2:18]1.[CH3:26][NH2:27]>>[CH3:26][NH:27][C:23]([CH:19]1[CH2:20][C:21](=[O:22])[N:17]([C:3]2[CH:4]=[CH:5][C:6]([O:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=3)=[CH:7][C:2]=2[F:1])[CH2:18]1)=[O:25]

Participants

Reactant 2

HCID 6329Methylamine

HCID 21920016HCID 21920016, compound

Product 1

HCID 10316454HCID 10316454, compound

Procedure

The title compound is prepared in analogy to Example 20d) from (RS)-1-[2-fluoro-4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid and methylamine. Yield: 39% of a brownish solid. MS: m/e=361.2 (M+H)+.

Sources & evidence

ORD record: ord-e552d7991f3d45b1a1f3465dce5c7b42
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07037935B2

Reaction notes

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