Itaconic acid → HCID 21920039, compound

HRID 1823054Notes

Reaction equation

HRID 1823054 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[C:17]([OH:25])(=[O:24])[C:18]([CH2:20][C:21](O)=[O:22])=[CH2:19]>>[F:1][C:2]1[CH:3]=[CH:4][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[CH:12][C:13]([N:16]3[C:21](=[O:22])[CH2:20][CH:18]([C:17]([OH:25])=[O:24])[CH2:19]3)=[CH:14][CH:15]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 811Itaconic acidHCID 64445694-[2-(4-Fluorophenyl)ethenyl]aniline

Product 1

HCID 21920039HCID 21920039, compound

Procedure

In an analogous manner to that described in Example 36c), the reaction of (E)-4-[2-(4-fluoro-phenyl)-vinyl]-phenylamine with itaconic acid yields the (RS)-(E)-1-{4-[2-(4-fluoro-phenyl)-vinyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid which was directly engaged in the next step without further purification and characterisation.

Sources & evidence

ORD record
ord-de334f9427914b19b594e21775691673
Source dataset
uspto-grants-2006_05
Patent number
US07037935B2

Reaction notes

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