Methylamine → HCID 10042869, compound

HRID 1823063Notes

Reaction equation

HRID 1823063 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[C:20](=[O:21])[CH2:19][CH:18]([C:22]([OH:24])=O)[CH2:17]3)=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:25][NH2:26]>>[CH3:25][NH:26][C:22]([CH:18]1[CH2:19][C:20](=[O:21])[N:16]([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[CH:11][CH:12]=2)[CH2:17]1)=[O:24]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 21920025HCID 21920025, compound

Product 1

HCID 10042869HCID 10042869, compound

Procedure

In an analogous manner to that described in Example 36d), the esterification of (RS)-1-{4-[2-(3-fluoro-phenyl)-ethyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid and reaction of the intermediate acid chloride with methylamine yields the (RS)-1-{4-[2-(3-fluoro-phenyl)-ethyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid methylamide as a light yellow solid; MS: m/e=341 (M+H)+.

Sources & evidence

ORD record
ord-5dff244982204ea3be01f40f328f02ed
Source dataset
uspto-grants-2006_05
Patent number
US07037935B2

Reaction notes

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