Itaconic acid → HCID 21920017, compound

HRID 1823066Notes

Reaction equation

HRID 1823066 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH:6]=[CH:7][CH:8]=1.[C:18]([OH:26])(=[O:25])[C:19]([CH2:21][C:22](O)=[O:23])=[CH2:20]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([N:17]3[C:22](=[O:23])[CH2:21][CH:19]([C:18]([OH:26])=[O:25])[CH2:20]3)=[CH:15][CH:16]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 811Itaconic acidHCID 142560284-[2-(3-Methoxyphenyl)ethyl]aniline

Product 1

HCID 21920017HCID 21920017, compound

Procedure

In an analogous manner to that described in Example 36c), the reaction of 4-[2-(3-methoxy-phenyl)-ethyl]-phenylamine with itaconic acid yields the (RS)-1-{4-[2-(3-methoxy-phenyl)-ethyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid as a white solid; MS: m/e=338 (M−H)+.

Sources & evidence

ORD record
ord-5d429f53b1384fbf9d6bb8973ea3fec6
Source dataset
uspto-grants-2006_05
Patent number
US07037935B2

Reaction notes

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