Hydrochloric Acid → HCID 24824485, compound

HRID 1823082Notes

Reaction equation

HRID 1823082 reaction equation
C(OC([N:8]([CH2:33][C@@H:34]([C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=1)[OH:35])[CH2:9][CH2:10][C:11]1[CH:32]=[CH:31][C:14]([O:15][C:16]2[CH:30]=[CH:29][C:19]([O:20][CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])=[CH:18][CH:17]=2)=[CH:13][CH:12]=1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:42].[Cl:42][C:38]1[CH:37]=[C:36]([C@@H:34]([OH:35])[CH2:33][NH:8][CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:15][C:16]3[CH:17]=[CH:18][C:19]([O:20][CH2:21][C:22]([OH:24])=[O:23])=[CH:29][CH:30]=3)=[CH:31][CH:32]=2)[CH:41]=[CH:40][CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24823791HCID 24823791, compound

Product 1

HCID 24824485HCID 24824485, compoundYield 180.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl [4-[4-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino]ethyl]phenoxy]phenoxy]acetate (305 mg) and 4N hydrochloride in 1,4-dioxane (5.0 ml) was stirred at room temperature for 24 hours. The resulting solid was collected by filtration and dried to give [4-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]phenoxy]phenoxy]-acetic acid hydrochloride (220 mg) as a white solid.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-6886566cf6274f30b0571c28397c1af4
Source dataset
uspto-grants-2006_05
Patent number
US07037938B2

Reaction notes

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