Hydrochloric Acid → HCID 69056068, compound

HRID 1823106Notes

Reaction equation

HRID 1823106 reaction equation
C([C:5]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[CH:8]=[CH:7][C:6]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][N:23](C(OC(C)(C)C)=O)[CH2:24][C@H:25]([OH:32])[C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:16][CH:15]=1)(C)(C)C.[ClH:40]>O1CCOCC1>[ClH:40].[ClH:40].[OH:32][C@H:25]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)[CH2:24][NH:23][CH2:22][CH2:21][CH2:20][C:17]1[CH:16]=[CH:15][C:14]([C:6]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][CH:5]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23569013HCID 23569013, compound

Product 1

HCID 69056068HCID 69056068, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4′-[3-[(tert-butoxycarbonyl)-[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]propyl]-1,1′-biphenyl-4-carboxylic acid (90 mg) and 4N hydrochloride in dioxane (5.0 ml) was stirred at room temperature for 24 hours. The resultant solid was collected by filtration and dried to give 4′-[3-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]-amino]propyl]-1,1′-biphenyl-4-carboxylic acid dihydrochloride (80 mg) as a white solid.

Workup

  1. filtrationThe resultant solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-164bd2a4f2fd4bf095af3e0d7402c8ad
Source dataset
uspto-grants-2006_05
Patent number
US07037938B2

Reaction notes

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