反应详情

温度

70 °C

To a solution of 4-hydroxy-1-naphthoic acid (2.18 g) in methanol (15 ml) was added sulfuric acid (1.0 ml), and the mixture was stirred at 70° C. for 3 hours. The solution was diluted with water and ethyl acetate. The organic layer was separated and washed with brine. The extract was dried over magnesium sulfate, filtrated and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel with ethyl acetate and hexane to give methyl 4-hydroxy-1-naphthoate (1.64 g) as a white solid.

1. customThe organic layer was separated
2. washwashed with brine
3. dry with materialThe extract was dried over magnesium sulfate
4. filtrationfiltrated
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by column chromatography on silica gel with ethyl acetate and hexane