Phenol → HCID 178461642, compound

HRID 1823192Notes

Reaction equation

CCOCC.C([Zn:8][CH2:9][CH3:10])C.[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CCCCCC>[CH2:9]([Zn:8][O:17][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:10]

Participants

Conditions

Temperature: -78 °C

Procedure

In the drybox, a 100-mL Schlenk flask was charged with Et2O (30 mL) and cooled to −78° C. Diethylzinc (9.0 mL of a 1.0 M hexane solution, 9.0 mmol) was added via syringe. A solution of phenol (0.847 g of phenol in 10 mL of Et2O) was added to the Schlenk flask, and the colorless reaction mixture was stirred at −78° C. for 1 h. The mixture was evaporated to give a white solid (1.593 g, 94%). 1H NMR (300 MHz, DMSO-d6): δ 7.1, 6.6 (m, 5H), 1.2 (t, 3H), 0.1 (m, 2H).

Workup

customThe mixture was evaporated

Sources & evidence

ORD record: ord-ca28a1fb516b4b65ad83d779f1380a62
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07037990B2

Reaction notes

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