Dimethylformamide dimethyl acetal → (2e)-3-(Dimethylamino)-1-(4-ethylphenyl)-2-imidazolylprop-2-en-1-one

HRID 1823453Notes

Reaction equation

HRID 1823453 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:16])[CH2:10][C:11]2[NH:12][CH:13]=[CH:14][N:15]=2)=[CH:5][CH:4]=1)[CH3:2].[CH3:17][N:18]([CH:20](OC)OC)[CH3:19]>>[CH3:17][N:18]([CH3:20])/[CH:19]=[C:10](\[C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)/[C:9]([C:6]1[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=1)=[O:16]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 221425781-(4-Ethylphenyl)-2-imidazolylethan-1-one

Product 1

HCID 22142876(2e)-3-(Dimethylamino)-1-(4-ethylphenyl)-2-imidazolylprop-2-en-1-one

Procedure

1 mmol of 1-(4-ethylphenyl)-2-imidazolylethan-1-one was heated to 80° C. in N,N-dimethylformamidedimethyl acetal for six hours and concentrated in vacuo to obtain (2E)-3-(dimethylamino)-1-(4-ethylphenyl)-2-imidazolylprop-2-en-1-one.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-78b2be32aee341c6b169f3e9b60926c2
Source dataset
uspto-grants-2006_05
Patent number
US07037918B2

Reaction notes

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