6-Chloro-3-nitropyridin-2-ylamine → HCID 178430859, compound

HRID 1823579Notes

Reaction equation

HRID 1823579 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([Cl:11])[CH:3]=1.[NH2:12][C:13]1[C:18]([N+:19]([O-:21])=[O:20])=[CH:17][CH:16]=[C:15](Cl)[N:14]=1.ClC1C=C(Cl)C=CC=1C1[C:36]([C:37]2[NH:38][CH:39]=[C:40]([CH3:42])[N:41]=2)=[CH:35][N:34]=[C:33]([NH:43][CH2:44][CH2:45][NH:46]C2N=CC(C#N)=CC=2)[N:32]=1>>[NH2:12][C:13]1[N:14]=[C:15]([NH:46][CH2:45][CH2:44][NH:43][C:33]2[N:32]=[C:6]([C:5]3[CH:9]=[CH:10][C:2]([F:1])=[CH:3][C:4]=3[Cl:11])[C:36]([C:37]3[NH:38][CH:39]=[C:40]([CH3:42])[N:41]=3)=[CH:35][N:34]=2)[CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20]

Participants

4

Reactant 3

HCID 27240356-Chloro-3-nitropyridin-2-ylamineHCID 27365462-Chloro-4-fluorobenzoyl chlorideHCID 178430853HCID 178430853, compound

Product 1

HCID 178430859HCID 178430859, compound

Procedure

{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2-chloro-4-fluorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]amine was prepared from 4-fluoro-2-chlorobenzoyl chloride and 2-amino-6-chloro-3-nitropyridine using the general method for 6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile.

Sources & evidence

ORD record
ord-90d8c6b454ea4868b4c793cb0185297e
Source dataset
uspto-grants-2006_05
Patent number
US07037918B2

Reaction notes

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