2-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione → 2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione

HRID 1823625Notes

Reaction equation

HRID 1823625 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:22])[CH2:10][N:11]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]1=[O:21]>CN(C(OC)OC)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:22])[C:10]([N:11]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]1=[O:21])=[CH:10][N:11]([CH3:19])[CH3:12]

Participants

3

Reactant 1

HCID 7367782-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 540183712-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione

Reagents, catalysts & solvents 1

HCID 78373Dimethylformamide dimethyl acetalSolvent

Procedure

1 mmol of 2-[2-(2,4-dichlorophenyl)-2-oxoethyl]isoindoline-1,3-dion was heated to 80° C. in neat N,N-dimethylformamidedimethyl acetal for six hours. The reaction mixture was concentrated in vacuo and purified by trituration with diethyl ether.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by trituration with diethyl ether

Sources & evidence

ORD record
ord-13c0c24a56c443bea9e199e45d7e15bd
Source dataset
uspto-grants-2006_05
Patent number
US07037918B2

Reaction notes

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