反应详情

To a one-liter four-necked flask were added 102.5 g (595 mmol) of ethyl (R,R)-2-hydroxycyclohexanecarboxylate and 400 mL of 2-propanol and stirring was started. Hydrazine monohydrate (44.7 g; 893 mmol) was dropped thereinto at 13° C. taking 30 minutes. After the dropping, the mixture was stirred at 80° C. for 9.5 hours. Followed by, heating was stopped and the mixture was cooled to room temperature to precipitate the crystals. The crystals were filtered and washed with a small amount of 2-propanol. The resulting crystals were dried to give 30.10 g of the title compound. The yield was 32%.

1. stirringAfter the dropping, the mixture was stirred at 80° C. for 9.5 hours
2. temperatureFollowed by, heating
3. customto precipitate the crystals
4. filtrationThe crystals were filtered
5. washwashed with a small amount of 2-propanol
6. customThe resulting crystals were dried