Cyclopentylamine → HCID 23570438, compound

HRID 1823790Notes

Reaction equation

HRID 1823790 reaction equation
[CH2:1]([NH:8][C:9]1[NH:10][C:11]2[CH:17]=[C:16]([O:18][S:19]([C:22]3[CH:27]=[CH:26][C:25](F)=[CH:24][CH:23]=3)(=[O:21])=[O:20])[CH:15]=[CH:14][C:12]=2[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:29]1([NH2:34])[CH2:33][CH2:32][CH2:31][CH2:30]1>CN1CCCC1=O>[CH2:1]([NH:8][C:9]1[NH:10][C:11]2[CH:17]=[C:16]([O:18][S:19]([C:22]3[CH:27]=[CH:26][C:25]([NH:34][CH:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:24][CH:23]=3)(=[O:21])=[O:20])[CH:15]=[CH:14][C:12]=2[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2906CyclopentylamineHCID 22146823HCID 22146823, compound

Product 1

HCID 23570438HCID 23570438, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of 4-fluoro-benzenesulfonic acid 2-benzylamino-3H-benzoimidazol-5-yl ester (20 mg) and cyclopentylamine (21 μl) in N-methylpyrrolidinone (0.5 ml) was heated at 110° C. in a sealed tube for 2 hours. The reaction mixture was then purified by triggered LC/MS to give 4-cyclopentylamino-benzenesulfonic acid 2-benzylamino-3H-benzoimidazol-5-yl ester as an off-white solid (4 mg). Mass spectrum: 463 [M+H]+; retention time=8.35 minutes.

Workup

  1. customThe reaction mixture was then purified by triggered LC/MS

Sources & evidence

ORD record
ord-2fbc3c6142e2454980d7ea6c200920b9
Source dataset
uspto-grants-2006_05
Patent number
US07041668B2

Reaction notes

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