4-(Trifluoromethyl)benzoyl chloride → HCID 22147888, compound

HRID 1823846Notes

Reaction equation

HRID 1823846 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:9][NH2:10])=[O:8].[F:11][C:12]([F:23])([F:22])[C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1>>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:9][NH:10][C:17](=[O:18])[C:16]1[CH:20]=[CH:21][C:13]([C:12]([F:11])([F:22])[F:23])=[CH:14][CH:15]=1)=[O:8]

Participants

3

Reactant 2

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 23570764HCID 23570764, compound

Product 1

HCID 22147888HCID 22147888, compound

Procedure

Compounds of this invention with Formula VI may be prepared as illustrated by the exemplary reaction in Scheme 6. Reaction of 3-chloro-thiophene-2-carboxylic acid hydrazide with 4-trifluoromethylbenzoyl chloride produces N-(3-chloro-thiophene-2-carbonyl)-N′-(4-trifluoromethylbenzoyl)-hydrazine, followed by treating with thionyl chloride produces 5-(3-chloro-2-thienyl)-3-(4-trifluoromethylbenzoyl)-[1,3,4]-oxadiazole.

Workup

  1. customas illustrated by the exemplary reaction in Scheme 6

Sources & evidence

ORD record
ord-8c11ac36092c41fea489ae76c4eae6e9
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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