3-Bromofuran-2-carboxylic acid → HCID 9901891, compound

HRID 1823869Notes

Reaction equation

HRID 1823869 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([OH:9])=O.[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([C:17](=[N:19]O)[NH2:18])=[N:15][CH:16]=1>>[Br:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]1[O:9][N:19]=[C:17]([C:14]2[CH:13]=[CH:12][C:11]([Cl:10])=[CH:16][N:15]=2)[N:18]=1

Participants

3

Reactant 2

HCID 6054793-Bromofuran-2-carboxylic acidHCID 136279893HCID 136279893, compound

Product 1

HCID 9901891HCID 9901891, compound

Procedure

The title compound was prepared from 3-bromo-furan-2-carboxylic acid (381.7 mg, 2.00 mmol) and 5-chloro-pyridine-2-amidoxime (343 mg, 2.00 mmol), similar to Example 70, and yielded 353 mg (54%) of white solid. 1H NMR (CDCl3): 8.81 (d, J=2.47 Hz, 1H), 8.22 (d, J=8.24 Hz, 1H), 7.90 (dd, J=8.25, 2.48 Hz, 1H), 7.71 (d, J=1.93 Hz, 1H), 6.79 (d, J=1.64 Hz, 1H).

Sources & evidence

ORD record
ord-2d61159cc5174d7291661c2c259c21a0
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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