3-Chlorothiophene-2-carbonyl chloride → HCID 22147858, compound

HRID 1823871Notes

Reaction equation

HRID 1823871 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:9][OH:10])[NH2:8])[N:6]=1.[Cl:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[C:17](Cl)=O>>[Cl:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[C:17]1[O:10][N:9]=[C:7]([C:5]2[N:6]=[C:2]([CH3:1])[S:3][CH:4]=2)[N:8]=1

Participants

3

Reactant 2

HCID 27358243-Chlorothiophene-2-carbonyl chlorideHCID 2744266HCID 2744266, compound

Product 1

HCID 22147858HCID 22147858, compound

Procedure

The title compound was prepared from 2-methyl-thiazole-4-amidoxime (24.6 mg, 0.156 mmol) and 3-chloro-thiophene-2-carbonyl chloride (28.7 mg, 0.159 mmol) similar to Example 16, and yielded 18.2 mg (40%) of white solid. 1H NMR (CDCl3): 8.03 (s, 1H), 7.61 (d, J=5.49 Hz, 1H), 7.13 (d, J=5.22 Hz, 1H), 2.84 (s, 3H).

Sources & evidence

ORD record
ord-f6861d2e74394ce88b60ae33371ffc9e
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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